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Paclitaxel
(
PTX
), sold under the brand name
Taxol
among others, is a
chemotherapy medication
used to treat a number of types of
cancer
. This includes
ovarian cancer
,
breast cancer
,
lung cancer
,
Kaposi sarcoma
,
cervical cancer
, and
pancreatic cancer
. It is given by
injection into a vein
.
[2]
There is also an
albumin bound formulation
.
[2]
Common side effects include hair loss,
bone marrow suppression
, numbness,
allergic reactions
, muscle pains, and
diarrhea
. Other serious side effects include heart problems, increased risk of infection, and
lung inflammation
.
[2]
There are concerns that use during pregnancy may cause
birth defects
.
[3]
[2]
Paclitaxel is in the
taxane
family of medications.
[4]
It works by interference with the normal function of
microtubules
during
cell division
.
[2]
Paclitaxel was first isolated in 1971 from the
Pacific yew
and approved for medical use in 1993.
[5]
[6]
It is on the
World Health Organization's List of Essential Medicines
, the most effective and safe medicines needed in a
health system
.
[7]
The wholesale cost in the
developing world
is about 7.06 to 13.48 USD per 100 mg vial.
[8]
This amount in the United Kingdom costs the
NHS
about 66.85 pounds.
[9]
It is now manufactured by
cell culture
.
[6]
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