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Testosterone is also used as a medication to treat male hypogonadism and certain types of breast cancer.Sincetestosterone levels gradually decrease as men age, synthetic testosterone is sometimes prescribed to older men to counteract this deficiency.

Testosterone is a steroid from the androstane class containing a keto and hydroxyl groups at the three and seventeen positions respectively. It is biosynthesized in several steps from cholesterol and is converted in the liver to inactive metabolites.It exerts its action through binding to and activation of the androgen receptor.

In humans and most other vertebrates, testosterone is secreted primarily by the testicles of males and, to a lesser extent, the ovaries of females. Small amounts are also secreted by the adrenal glands. On average, in adult males, levels of testosterone are about 7–8 times as great as in adult females.As the metabolic consumption of testosterone in males is greater, the daily production is about 20 times greater in men.Females are also more sensitive to the hormone.

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Nicotinamide mononucleotide ("NMN" and "β-NMN") is a nucleotide derived from ribose and nicotinamide.Niacinamide (nicotinamide) is a derivative of vitamin B3, also known as niacin.As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra.

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In studies on mice, NMN has shown to reverse age-related arterial dysfunction by decreasing oxidative stress.A long-term study indicates that NMN can slow down the physiologic decline in ageing mice.As a result, the older mice in the study have metabolism and energy levels resembling those of younger mice, with extended life spans. However, NMN did not show similar beneficial effects in young mice.

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